Matenda a mtima, omwe ndi omwe amayambitsa kufa kwa matenda osapatsirana, makamaka ndi matenda obwera chifukwa cha ukalamba.Ndi kukula kwa ukalamba, mtima, monga chiwalo chopopa magazi, udzakalamba, ndipo mphamvu yake yopumula ndi mgwirizano idzachepa, ndipo pang'onopang'ono sudzatha kutulutsa magazi ku thupi lonse, zomwe zidzachititsa kuti mtima ulephereke. odwala ndi kukhudza kwambiri moyo wathanzi wa anthu.
Kukalamba kwa mtima kumadziwika ndi kuchepa kwa contractility ya mtima (mtima wogwira ntchito), womwe umatsagana ndi kuchepa kwa kuchuluka kwa mapuloteni komanso kusintha kwa mapuloteni pambuyo pomasulira.
SS-31 peptide ndi cardiolipin peroxidase inhibitor ndi mitochondrial yolunjika peptide.Ikhoza kusintha ntchito ya ventricle yakumanzere ndi mitochondria.SS-31 peptide imatha kuchepetsa kukanika kwa mitochondrial ndi kuwonongeka kwa okosijeni m'maselo a trabecular meshwork amunthu.Ikhoza kuteteza maselo a iHTM ndi GTM (3) kuti asamangokhalira kupanikizika ndi okosijeni chifukwa cha H2O2.
SS-31 ndi mankhwala a mitochondrial omwe amalimbana ndi kukalamba, zomwe zatsimikiziridwa kuti ndizothandiza kubwezeretsa mtima wa mbewa zachikulire.Ndi tetrapeptide yopangidwa yomwe imaphatikizidwa ndi nembanemba yamkati ya mitochondrial, yomwe imatha kupititsa patsogolo ntchito ya mitochondrial, kuchepetsa kupanga kwamtundu wa okosijeni wokhazikika wa ROS, kuchepetsa kuchuluka kwa zinthu zoyambitsa kutupa komanso kupititsa patsogolo ntchito ya diastolic ya mtima.
Choyamba, kuyerekeza mbewa zazing'ono ndi mbewa zakale, asayansi adapeza kuti kuchuluka kwa mapuloteni a mitochondrial kumakhudzidwa makamaka ndi ukalamba, kuphatikizapo njira yopatsira chizindikiro cha mitochondrial, mapuloteni okhudzana ndi njira ya oxidative phosphorylation yomwe imapanga mphamvu, ndi mapuloteni okhudzana ndi njira yodutsa chizindikiro cha SIRT yokhudzana ndi mphamvu. metabolism mu mitochondria.Kuphatikiza apo, mapuloteni ofunikira a troponin ndi tropomyosin, omwe amalumikizana mwachindunji ndi kugunda kwa myocardial, amakhudzidwanso ndi ukalamba.Izi zimagwirizana kwambiri ndi ntchito ya mtima.Kachiwiri, poganizira momwe chithandizo cha SS-31 chimakhudzira, ofufuzawo adapeza kuti kuchuluka kwa mapuloteni a mbewa zakale zomwe adachiritsidwa sizikuwoneka kuti zikugwirizana ndi gulu laling'ono, koma onse adawonetsa kuchira kwa njira yotsekereza ndi ukalamba, monga kuchuluka kwa mapuloteni a tricarboxylic acid cycle, njira yayikulu yopangira mphamvu m'thupi, yomwe idachira kwambiri, kupangitsa mbewa zakale kukhala zazing'ono.Izi zikutanthauza kuti SS-31 ndiyothandiza makamaka pakusintha kwamphamvu kagayidwe kazakudya komwe kumachitika chifukwa cha ukalamba wamtima.Kufufuza kwa kuchuluka kwa mapuloteni kunatha, ndipo ochita kafukufuku adatembenukira ku kusintha kwa kusintha kwa mapuloteni pambuyo pomasulira panthawi ya ukalamba, ndipo makamaka anasankha kusintha kofala kwambiri pambuyo pomasulira mu mapuloteni, omwe amagwirizana kwambiri ndi mtima. - Kusintha kwa acetylation.Pakhoza kukhala kusintha kuwiri pakusintha kwa acetylation.Choyamba, chifukwa chakuti acetylation ya mapuloteni a mitochondrial idzawonjezeka ndi zaka, zomwe zimapangitsa kuti mitochondrial iwonongeke, ndipo mitochondrial yomwe ili pamtima imakhala yochuluka kwambiri, kotero kuti mtima wonse ukhoza kukhala ndi kuchuluka kwa acetylation pamene ntchito ya mtima ikuchepa;Chachiwiri, padzakhala kutayika kwa acetylation yachibadwa ya zotsalira zenizeni mu ukalamba, zomwe zidzatsogolera kulephera kusewera ntchito yake yachibadwa.Ofufuza alemeretsa ma peptides a acetylated mu mtima (omwe amatha kumveka ngati timagulu tating'ono tomwe timapanga mapuloteni).Palinso kusiyana pakati pa acetylation ya mapuloteni a mtima pakati pa gulu laling'ono ndi gulu lakale, koma sizikuwonekeratu monga kuchuluka kwa mapuloteni.Kenaka adafufuzanso kuti ndi mapuloteni ati omwe kusintha kwa acetylation kungakhale kwachindunji.Potsirizira pake, ochita kafukufuku adagwirizanitsanso mphamvu ya systolic ndi diastolic ya mtima ndipo adapeza malo a 14 acetylation okhudzana ndi mphamvu ya diastolic ya mtima, ndipo zonsezi zinali zolakwika.Pa nthawi yomweyi, malo awiri okhudzana ndi mgwirizano wa mtima adapezekanso.Izi zikutanthauza kuti kusintha kwa contractility pa ukalamba kumatha kuyendetsedwa ndi acetylation state ya protein protein.
Ndife opanga ma polypeptide ku China, omwe ali ndi zaka zingapo okhwima pakupanga polypeptide.Hangzhou Taijia Biotech Co., Ltd. ndi katswiri wopanga polypeptide yaiwisi, yomwe imatha kupereka makumi masauzande azinthu zopangira polypeptide ndipo imathanso kusinthidwa malinga ndi zosowa.Ubwino wa zinthu za polypeptide ndi zabwino kwambiri, ndipo chiyero chimatha kufika 98%, chomwe chadziwika ndi ogwiritsa ntchito padziko lonse lapansi.
