Mu madzi am'mimba a anthu, BPC 157 imakhala yokhazikika kwa maola oposa 24, motero imakhala ndi bioavailability yabwino yapakamwa (nthawi zonse imaperekedwa yokha) ndi zotsatira zopindulitsa m'mimba yonse ya m'mimba .Izi ndizosiyana kwambiri ndi ma peptides ena ovomerezeka, omwe amagwira ntchito kumadalira kuwonjezereka kwa chonyamulira kapena amawonongeka mofulumira mu madzi a m'mimba.Tikuwonetsa kuti chopereka cha BPC 157 ku cytoprotection ya Robert - ndiko kuti, kutha kuthana ndi zilonda zam'mimba zomwe zimayambitsidwa ndi mowa, zomwe Robert adazitcha kuti cytoprotection - komanso kuthekera kothana ndi zotupa zomwe zimabwera chifukwa cholumikizana mwachindunji ndi woyipayo ndi selo. imayimira mgwirizano wozungulira pakati pa matumbo ndi ubongo.
Perovic adanena kuti BPC 157 ili ndi chithandizo chodziwika bwino chokhudza kuchira kwa makoswe ndi kuvulala kwa msana ndi mchira wa ziwalo (1-minute compression kuvulala kwa sacrocaudal spinal cord [S2-Co1]).Mwachindunji, utsogoleri umodzi wa intraperitoneal BPC 157 pa mphindi za 10 pambuyo povulazidwa umatsutsana ndi zotsatira zoipa.Mosiyana ndi zimenezi, kuvulala kwa msana ndi kupweteka kwa mchira kumapitirirabe makoswe osagwiritsidwa ntchito, masiku oyesedwa, masabata, miyezi, ndi chaka chitatha kuvulala.Dziwani kuti, BPC 157 imachepetsa kuwonongeka komwe kumachitika kawirikawiri.Potero, chithandizo cha BPC 157 chimapangitsa kuti ziwoneke bwino, zowoneka bwino, komanso kuchira kwa electrophysiologic.
Zindikirani, mu makoswe omwe ali ndi vuto la msana, pali kubwereza kosatha.BPC 157 ikangoperekedwa kwa mphindi 10 pambuyo pa kuvulala kwapang'onopang'ono, pali chitetezo chosalekeza ndipo palibe chisokonezo chodzidzimutsa cha msana chomwe chimabweranso.
Chifukwa chake, ndizotheka kuti hemostasis yoyambirira ikhoza kukhala yopindulitsa ndikupangitsa kuchira pambuyo pa kusokonezeka kwa msana mu makoswe.Komabe, zotsatira za BPC 157 ndizosiyana ndi zosavuta za hemostatic zomwe zingachepetse kuvulala kwa msana, chifukwa BPC 157 imapangitsanso bwino ntchito ya thrombocyte mu makoswe popanda kukhudza zinthu zomwe zimagwirizanitsa.Panthawi yochira chifukwa cha kuvulala kwa msana, BPC 157 imatetezanso endothelium mwachindunji, imachepetsa kusokonezeka kwa mitsempha ya mitsempha, imayambitsa mofulumira njira zina zodutsamo, ndipo imatsutsana ndi ma syndromes otchedwa venous occlusion-induced syndromes.Choncho, poganiza kuti pali chithandizo chochuluka cha venous ku mitsempha ya msana, n'zotheka kuti kubwezeretsedwa kwa magazi komwe kumayendetsedwa ndi BPC 157 mosakayikira kungathandize kuti ayambe kuchira msanga.Komanso, poganizira kuti BPC 157 imalimbikitsa kubwereza kosatha pambuyo pa kupanikizika kwa msana, ziyenera kuzindikiridwa kuti pamene BPC 157 imaperekedwa panthawi yobwezeretsanso, imatsutsana ndi sitiroko yomwe imayambitsidwa ndi kugwedeza kwapakati kwa mitsempha ya carotid.BPC 157 imathetsa kuwonongeka kwa ma neuronal ndikulepheretsa kukumbukira, kuyendetsa galimoto, ndi kuperewera kwa mgwirizano.BPC 157 mwachiwonekere imakhala ndi zotsatirazi mwa kusintha maonekedwe a majini mu hippocampus.
Pomaliza, BPC 157 imakhala ndi zotsatira zopindulitsa pa sitiroko, schizophrenia, ndi kuvulala kwa msana.
Ofufuza awonetsa mosalekeza kuti BPC 157 imakhala ndi zopindulitsa zambiri mthupi lonse.Palibe chifukwa chosonyezera kuti ubwino wa BPC 157 ndi wochepa chifukwa cha kuvomerezeka kwa zitsanzo zomwe zimagwiritsidwa ntchito ndi / kapena zolepheretsa njira.Zowonadi, titha kunena kuti mphamvu, kugwiritsa ntchito mosavuta, mbiri yotetezeka yazachipatala ndi njira ya BPC 157 imayimira njira ina, yotheka, yopambana, yochiritsira yamtsogolo pamikhalidwe yaubongo.Choncho, maphunziro owonjezera amafunikira kuti afotokoze momwe chithandizo cha BPC 157 chingagwiritsire ntchito makamaka njira yochitirapo kanthu yomwe imaphatikizapo malo angapo a subcellular mu CNS.Chikoka pa ntchito ya ambiri, ngati si onse, machitidwe a neuronal pamamolekyulu, ma cell, ndi machitidwe akuyenera kufufuzidwa.Zina mwazinthu zobwerezabwereza zobwerezabwereza za CNS kapena ziwalo zozungulira, chimodzi mwa zigawo zochepa za ubongo popanda chotchinga chamagazi-muubongo, ndi njira yodziwika yomwe peptide yoyendetsedwa mwadongosolo imatha kuchitapo kanthu.Choncho, iyenera kuchita mkati mwa matumbo a ubongo, mosasamala kanthu kuti izi ndi zachindunji kapena zosalunjika.
